Dr Shafagh Waters

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Dr Shafagh Waters

Senior Lecturer

PhD, Australian National University

MSc (Distinction), University of Otago, New Zealand��

BSc, The University of Auckland, New Zealand

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Medicine & Health

School of Biomedical Sciences

Dr Shafagh Waters (BSc, MSc (Disc.), PhD)��is a Scientia senior lecturer��at ��logo and an honorary senior scientist at Sydney Children’s Hospital. A productive PhD (2012; ANU) and postdoctoral fellowships (2013-2016; ��logo) helped her secure international training fellowships in gene therapy and organoid medicine,��establishing her independent lab in 2016.��Dr Waters��lead an NHMRC funded research program on adult-stem-cell biology for cystic fibrosis (CF) that is supported by 32 grants; 21 as CIA including international��and national industry partnerships. Dr Waters has developed an Australian national biobank of stem-cell-derived airway and gut organoids, and has built a platform for high-throughput therapy-testing on patients organoids. She combines her unique strengths in organoid disease modelling, multi-omic molecular profiling and computational research with clinical data to improve individualised outcomes for patients with CF. She��is regularly��invited to media interviews and present at community, and as a keynote speaker at national and international meetings, on two occasions, and was the recipient of the best ECR research award at the 2019-Australian Academy of Science, Precision Medicine^��Conference. In 2020, the latter (co-culture airway organoid with pathogens) was pivoted to COVID-19 to delineate the innate immune response to SARS-CoV2 infection.

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Phone

+61 (2)93856961

E-mail

shafagh.waters@unsw.edu.au

Location

The School of Medical Sciences is located in the Wallace Wurth Building (upper campus of ��logo) which is accessible via Gate 9, High Street, Randwick.

Book Chapters | 2018

McIntyre K; Waters S; Waters P, 2018, 'Sex Chromosomes', in Skinner MK (ed.), Encyclopedia of Reproduction, Academic Press, pp. 238 - 244,

Book Chapters | 2010

Al Nadaf S; Waters PD; Deakin JE; Graves JAM, 2010, 'Marsupial genetics reveals insights into evolution of mammalian X chromosome inactivation', in Marsupial Genetics and Genomics, pp. 259 - 280,
Journal articles | 2025

Fawcett LK; Waters SA; Jaffe A, 2025, 'The equitable challenges to quality use of modulators for cystic fibrosis in Australia', Medical Journal of Australia, 222, pp. 4 - 9,

Journal articles | 2024

Carrera Montoya J; Collett S; Fernandez Ruiz D; Earnest L; Edeling MA; Yap AHY; Wong CY; Cooney JP; Davidson KC; Roberts J; Rockman S; Tran BM; McAuley JL; Deliyannis G; Grimley SL; Purcell DFJ; Waters SA; Godfrey DI; Hans D; Pellegrini M; Mackenzie JM; Vincan E; Heath WR; Torresi J, 2024, 'Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine', Organoids, 3, pp. 18 - 31,

Journal articles | 2024

Chang JJY; Grimley SL; Tran BM; Deliyannis G; Tumpach C; Nguyen ANT; Steinig E; Zhang JS; Schröder J; Caly L; McAuley J; Wong SL; Waters SA; Stinear TP; Pitt ME; Purcell D; Vincan E; Coin LJM, 2024, 'Uncovering strain- and age-dependent innate immune responses to SARS-CoV-2 infection in air-liquid-interface cultured nasal epithelia', iScience, 27,

Journal articles | 2024

Lister NC; Milton AM; Patel HR; Waters SA; Hanrahan BJ; McIntyre KL; Livernois AM; Horspool WB; Wee LK; Ringel AR; Mundlos S; Robson MI; Shearwin-Whyatt L; Grützner F; Marshall Graves JA; Ruiz-Herrera A; Waters PD, 2024, 'Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation', Proceedings of the National Academy of Sciences of the United States of America, 121,

Journal articles | 2024

McIntyre KL; Waters SA; Zhong L; Hart-Smith G; Raftery M; Chew ZA; Patel HR; Graves JAM; Waters PD, 2024, 'Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation', Genome Biology, 25,

Journal articles | 2024

Umashankar B; Eliasson L; Ooi CY; Kim KW; Shaw JAM; Waters SA, 2024, 'Beyond insulin: Unraveling the complex interplay of ER stress, oxidative damage, and CFTR modulation in CFRD', Journal of Cystic Fibrosis, 23, pp. 842 - 852,

Journal articles | 2024

Waters S; Middleton PG, 2024, 'Rectal organoid morphometric analysis (ROMA)-re: Optimising measurements automatically', Thorax, 79, pp. 801 - 802,

Journal articles | 2023

Allan KM; Astore MA; Kardia E; Wong SL; Fawcett LK; Bell JL; Visser S; Chen PC; Griffith R; Jaffe A; Sivam S; Vittorio O; Kuyucak S; Waters SA, 2023, 'Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient', Frontiers in Molecular Biosciences, 10,

Journal articles | 2023

Fawcett LK; Jaffe A; Waters SA, 2023, 'WS14.02 Cystic fibrosis personalised medicine; paediatric in vitro airway cell models to predict CFTR modulator patient outcomes', Journal of Cystic Fibrosis, 22, pp. S28 - S28,

Journal articles | 2023

Fawcett LK; Turgutoglu N; Allan KM; Belessis Y; Widger J; Jaffe A; Waters SA, 2023, 'Comparing Cytology Brushes for Optimal Human Nasal Epithelial Cell Collection: Implications for Airway Disease Diagnosis and Research', Journal of Personalized Medicine, 13, pp. 864,

Journal articles | 2023

Molley TG; Jiang S; Ong L; Kopecky C; Ranaweera CD; Jalandhra GK; Milton L; Kardia E; Zhou Z; Rnjak-Kovacina J; Waters SA; Toh YC; Kilian KA, 2023, 'Gas-modulating microcapsules for spatiotemporal control of hypoxia', Proceedings of the National Academy of Sciences of the United States of America, 120, pp. e2217557120,

Journal articles | 2023

Nguyen AK; Molley TG; Kardia E; Ganda S; Chakraborty S; Wong SL; Ruan J; Yee BE; Mata J; Vijayan A; Kumar N; Tilley RD; Waters SA; Kilian KA, 2023, 'Hierarchical assembly of tryptophan zipper peptides into stress-relaxing bioactive hydrogels', Nature Communications, 14,

Journal articles | 2023

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, pp. 132,

Journal articles | 2023

Westhaus A; Cabanes-Creus M; Dilworth KL; Zhu E; Salas Gómez D; Navarro RG; Amaya AK; Scott S; Kwiatek M; McCorkindale AL; Hayman TE; Frahm S; Perocheau DP; Tran BM; Vincan E; Wong SL; Waters SA; Riddiough GE; Perini MV; Wilson LOW; Baruteau J; Diecke S; González-Aseguinolaza G; Santilli G; Thrasher AJ; Alexander IE; Lisowski L, 2023, 'Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors', Human Gene Therapy, 34, pp. 273 - 288,

Journal articles | 2023

Wong SL; Kardia E; Vijayan A; Umashankar B; Pandzic E; Zhong L; Jaffe A; Waters SA, 2023, 'Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia', International Journal of Molecular Sciences, 24,

Journal articles | 2022

Allan KM; Astore MA; Fawcett LK; Wong SL; Chen PC; Griffith R; Jaffe A; Kuyucak S; Waters SA, 2022, 'S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell models', Frontiers in Pediatrics, 10, pp. 1062766,

Journal articles | 2022

Astore MA; Chen P-C; Waters S; Kuyucak S, 2022, 'Computer modelling the root cause of cystic fibrosis', BIOPHYSICAL JOURNAL, 121, pp. 506A - 506A,

Journal articles | 2022

Dunnet MJ; Ortega-Recalde OJ; Waters SA; Weeks RJ; Morison IM; Hore TA, 2022, 'Leukocyte-specific DNA methylation biomarkers and their implication for pathological epigenetic analysis', Epigenetics Communications, 2,

Journal articles | 2022

Tran BM; Grimley SL; McAuley JL; Hachani A; Earnest L; Wong SL; Caly L; Druce J; Purcell DFJ; Jackson DC; Catton M; Nowell CJ; Leonie L; Deliyannis G; Waters SA; Torresi J; Vincan E, 2022, 'Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection', International Journal of Molecular Sciences, 23,

Journal articles | 2022

Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen PC; Capraro A; Fawcett LK; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity', iScience, 25, pp. 103710,

Journal articles | 2022

Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen PC; Setiadi J; Pandzic E; Fawcett LK; Widger JR; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect', American Journal of Respiratory Cell and Molecular Biology, 67, pp. 99 - 111,

Journal articles | 2022

Wong SL; Pandzic E; Kardia E; Allan KM; Whan RM; Waters SA, 2022, 'Quantifying Intracellular Viral Pathogen: Specimen Preparation, Visualization and Quantification of Multiple Immunofluorescent Signals in Fixed Human Airway Epithelium Cultured at Air-Liquid Interface', Journal of Personalized Medicine, 12,

Journal articles | 2021

Allan KM; Wong SL; Fawcett LK; Capraro A; Jaffe A; Herbert C; Pandzic E; Waters SA, 2021, 'Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency', Journal of Visualized Experiments,

Journal articles | 2021

Allan KM; Wong SL; Fawcett LK; Capraro A; Jaffe A; Herbert C; Pandzic E; Waters SA, 2021, 'Collection, expansion, and differentiation of primary human nasal epithelial cell models for quantification of cilia beat frequency', Journal of Visualized Experiments,

Journal articles | 2021

Allen K; Jaffe A; Waters S; Allan K, 2021, 'Treatment of Cystic Fibrosis: From Gene- to Cell-Based Therapies', Frontiers in Pharmacology, 12, pp. 639475,

Journal articles | 2021

Awatade N; Wong S; Capraro A; Pandzic E; Slapetova I; Zhong L; Fawcett L; Whan R; Jaffe A; Waters S, 2021, 'Significant functional differences in differentiated Conditionally Reprogrammed (CRC)- and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells', Journal of Cystic Fibrosis, 20, pp. 364 - 371,

Journal articles | 2021

Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, 2021, 'Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action', Patterns, 2, pp. 100325,

Journal articles | 2021

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', ,

Journal articles | 2021

Deshpande NP; Riordan SM; Gorman CJ; Nielsen S; Russell TL; Correa-Ospina C; Fernando BSM; Waters SA; Castaño-Rodríguez N; Man SM; Tedla N; Wilkins MR; Kaakoush NO, 2021, 'Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus', Genome Medicine, 13, pp. 133,

Journal articles | 2021

Fawcett LK; Wakefield CE; Sivam S; Middleton PG; Wark P; Widger J; Jaffe A; Waters SA, 2021, 'Avatar acceptability: Views from the australian cystic fibrosis community on the use of personalised organoid technology to guide treatment decisions', ERJ Open Research, 7, pp. 1 - 10,

Journal articles | 2021

Prentice BJ; Jaffe A; Hameed S; Verge CF; Waters S; Widger J, 2021, 'Cystic fibrosis-related diabetes and lung disease: An update', European Respiratory Review, 30, pp. 200293,

Journal articles | 2021

Villamizar O; Waters SA; Scott T; Grepo N; Jaffe A; Morris KV, 2021, 'Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator', Journal of Extracellular Vesicles, 10, pp. e12053,

Journal articles | 2020

Awatade N; Wong S; Pandzic E; Slapetova I; Capraro A; Zhong L; Turgutoglu N; Fawcett L; Whan R; Jaffe A; Waters S, 2020, 'Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells', ,

Journal articles | 2020

Capraro A; O‘Meally D; Waters SA; Patel HR; Georges A; Waters PD, 2020, 'MicroRNA dynamics during hibernation of the Australian central bearded dragon (Pogona vitticeps)', Scientific Reports, 10, pp. 17854,

Journal articles | 2020

Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S; Hart-Smith G; Zhong L; Pandzic E; Fernando BSM; Awatade N; Wong S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, 9, pp. 1 - 19,

Journal articles | 2020

Coffey MJ; Mckay IR; Doumit M; Chuang S; Adams S; Stelzer-Braid S; Waters SA; Kasparian NA; Thomas T; Jaffe A; Katz T; Ooi CY, 2020, 'Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital', BMJ Open, 10, pp. e033916,

Journal articles | 2020

Hewson C; Capraro A; Wong S; Pandzic E; Fernando BSM; Awatade N; Zhong L; Hart-Smith G; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, 'Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in anin vitrocystic fibrosis model', ,

Journal articles | 2019

Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'Tu1872 – The Human Intestinal Proteome in Children with Cystic Fibrosis', Gastroenterology, 156, pp. S - 1153,

Journal articles | 2019

Prentice BJ; Ooi CY; Strachan RE; Hameed S; Ebrahimkhani S; Waters SA; Verge CF; Widger J, 2019, 'Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis', Journal of Cystic Fibrosis, 18, pp. 869 - 873,

Journal articles | 2019

Sprague D; Waters SA; Kirk JM; Wang JR; Samollow PB; Waters PD; Calabrese JM, 2019, 'Nonlinear sequence similarity between the Xist and Rsx long noncoding RNAs suggests shared functions of tandem repeat domains', RNA, 25, pp. 1004 - 1019,

Journal articles | 2019

Villamizar O; Waters SA; Scott T; Saayman S; Grepo N; Urak R; Davis A; Jaffe A; Morris KV, 2019, 'Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator', Molecular Therapy, 27, pp. 1737 - 1748,

Journal articles | 2019

Waters S; Waters P; Capraro A, 2019, 'Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps', BMC Genomics, 20, pp. 460,

Journal articles | 2018

Awatade N; Wong S; Jaffe A; Waters S; Fawcett L, 2018, 'Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine', Frontiers in Pharmacology, 9, pp. 1429,

Journal articles | 2018

Johnson RN; O’Meally D; Chen Z; Etherington GJ; Ho SYW; Nash WJ; Grueber CE; Cheng Y; Whittington CM; Dennison S; Peel E; Haerty W; O’Neill RJ; Colgan D; Russell TL; Alquezar-Planas DE; Attenbrow V; Bragg JG; Brandies PA; Chong AYY; Deakin JE; Di Palma F; Duda Z; Eldridge MDB; Ewart KM; Hogg CJ; Frankham GJ; Georges A; Gillett AK; Govendir M; Greenwood AD; Hayakawa T; Helgen KM; Hobbs M; Holleley CE; Heider TN; Jones EA; King A; Madden D; Graves JAM; Morris KM; Neaves LE; Patel HR; Polkinghorne A; Renfree MB; Robin C; Salinas R; Tsangaras K; Waters PD; Waters SA; Wright B; Wilkins MR; Timms P; Belov K, 2018, 'Adaptation and conservation insights from the koala genome', Nature Genetics, 50, pp. 1102 - 1111,

Journal articles | 2018

Waters SA; Capraro A; McIntyre KL; Graves JAM; Waters PD, 2018, 'The methylome of vertebrate sex chromosomes', Genes, 9, pp. 230,

Journal articles | 2018

Waters SA; Livernois AM; Patel H; O’Meally D; Craig JM; Marshall Graves JA; Suter CM; Waters PD, 2018, 'Landscape of DNA methylation on the marsupial x', Molecular Biology and Evolution, 35, pp. 431 - 439,

Journal articles | 2017

Waters SA; McAteer SP; Kudla G; Pang I; Deshpande NP; Amos TG; Leong KW; Wilkins MR; Strugnell R; Gally DL; Tollervey D; Tree JJ, 2017, 'Small RNA interactome of pathogenic E.��coli revealed through crosslinking of RNase E', EMBO Journal, 36, pp. 374 - 387,

Journal articles | 2016

Alinejad-Rokny H; Anwar F; Waters SA; Davenport MP; Ebrahimi D, 2016, 'Source of CpG depletion in the HIV-1 genome', Molecular Biology and Evolution, 33, pp. 3205 - 3212,

Journal articles | 2015

Waters SA; Waters PD, 2015, 'Imprinted X chromosome inactivation: evolution of mechanisms in distantly related mammals', AIMS GENETICS, 2, pp. 110 - 126,

Journal articles | 2014

Rodríguez-Delgado CL; Waters SA; Waters DP; Waters P, 2014, 'Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials', BMC Evolutionary Biology, 14, pp. 267,

Journal articles | 2013

Livernois AM; Waters SA; Deakin JE; Marshall Graves JA; Waters PD, 2013, 'Independent Evolution of Transcriptional Inactivation on Sex Chromosomes in Birds and Mammals', PLoS Genetics, 9, pp. e1003635,

Journal articles | 2011

Al Nadaf S; Deakin JE; Gilbert C; Robinson TJ; Graves JA; Waters PD; Waters P, 2011, 'A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.', Chromosoma, 121, pp. 71 - 78,

Journal articles | 2011

Renfree MB; Papenfuss AT; Deakin JE; Lindsay J; Heider T; Belov K; Rens W; Waters PD; Pharo EA; Shaw G; Wong ESW; Lefèvre CM; Nicholas KR; Kuroki Y; Wakefield MJ; Zenger KR; Wang C; Ferguson-Smith M; Nicholas FW; Hickford D; Yu H; Short KR; Siddle HV; Frankenberg SR; Chew KY; Menzies BR; Stringer JM; Suzuki S; Hore TA; Delbridge ML; Mohammadi A; Schneider NY; Hu Y; O'Hara W; Al Nadaf S; Wu C; Feng ZP; Cocks BG; Wang J; Flicek P; Searle SMJ; Fairley S; Beal K; Herrero J; Carone DM; Suzuki Y; Sugano S; Toyoda A; Sakaki Y; Kondo S; Nishida Y; Tatsumoto S; Mandiou I; Hsu A; McColl KA; Lansdell B; Weinstock G; Kuczek E; McGrath A; Wilson P; Men A; Hazar-Rethinam M; Hall A; Davis J; Wood D; Williams S; Sundaravadanam Y; Muzny DM; Jhangiani SN; Lewis LR; Morgan MB; Okwuonu GO; Ruiz SJ; Santibanez J; Nazareth L; Cree A; Fowler G; Kovar CL; Dinh HH; Joshi V; Jing C; Lara F; Thornton R; Chen L; Deng J; Liu Y; Shen JY; Song XZ; Edson J; Troon C; Thomas D; Stephens A; Yapa L; Levchenko T; Gibbs RA; Cooper DW; Speed TP; Fujiyama A; M Graves JA; O'Neill RJ, 2011, 'Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development', Genome Biology, 12, pp. 414,

Journal articles | 2011

Royds JA; Al Nadaf S; Wiles AK; Chen YJ; Ahn A; Shaw A; Bowie S; Lam F; Baguley BC; Braithwaite AW; MacFarlane MR; Hung NA; Slatter TL, 2011, 'The cdkn2a g500 allele is more frequent in gbm patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival', PLoS ONE, 6, pp. e26737,

Journal articles | 2010

Al Nadaf S; Waters PD; Koina E; Deakin JE; Jordan KS; Graves JAM; Waters P, 2010, 'Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic', Genome Biology, 11, pp. r122,
Preprints | 2024

Gödde N; O’Brien C; Vincan E; Vashi A; Olliff S; Tran B; Waters S; Goldie S; van Vuren PJ; Riddell S; Bruce M; Agarwal V; Athan E; Blasdell K; Chahal S; Creek D; Faheem ; Jain H; Kirkpatrick C; Kumar A; MacRaild C; Muzaffar-Ur-Rehman M; Sankaranarayanan M; Shah R; Styles I; Tachedjian M; Trevaskis N; Singanallur N; McAuley A; Vasan S, 2024, Use of Stem Cell-Derived Cardiomyocyte and Nasal Epithelium Models to Establish a Multi-Tissue Model Platform to Validate Repurposed Drugs Against SARS-CoV-2 Infection,

Preprints | 2023

Chang JJ-Y; Grimley S; Tran BM; Deliyannis G; Tumpach C; Steinig E; Wong SL; Waters SA; Stinear TP; Pitt ME; Purcell D; Vincan E; Coin LJM, 2023, Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing,

Preprints | 2023

Lister N; Milton A; Patel H; Waters S; Hanrahan B; McIntyre K; Livernois A; Wee LK; Ringel A; Mundlos S; Robson M; Shearwin-Whyatt L; Grützner F; Marshall Graves J; Ruiz-Herrera A; Waters P, 2023, Incomplete transcriptional dosage compensation of vertebrate sex chromosomes is balanced by post-transcriptional compensation,

Preprints | 2023

McIntyre K; Waters S; Zhong L; Hart-Smith G; Raftery M; Graves JM; Waters P, 2023, Functional coherence of theXistandRSXprotein interactomes: X chromosome inactivation in marsupials,

Preprints | 2022

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Zheng Y; Rouaen J; Jue TR; Michniewicz FT; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Valli E; Brettle M; Whan R; Vahadat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2022, Copper chelation inhibits TGF-βpathways and suppresses epithelial-mesenchymal transition in cancer,

Preprints | 2022

Westhaus A; Cabanes-Creus M; Dilworth KL; Zhu E; Gómez DS; Navarro RG; Amaya AK; Scott S; Kwiatek M; McCorkindale AL; Hayman TE; Frahm S; Perocheau DP; Tran BM; Vincan E; Wong SL; Waters SA; Wilson LOW; Baruteau J; Diecke S; González-Aseguinolaza G; Santilli G; Thrasher AJ; Alexander IE; Lisowski L, 2022, Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors,

Preprints | 2021

Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, 2021, An Integrative Resource for Network-Based Investigation of COVID-19 Combinatorial Drug Repositioning and Mechanism of Action,

Preprints | 2021

Azad AKM; Fatima S; Capraro A; Waters SA; Vafaee F, 2021, An Integrative Resource for Network-Based Investigation of COVID-19 Combinatorial Drug Repositioning and Mechanism of Action, ,

Conference Abstracts | 2021

Waters S, 2021, 'Molecular Dynamics to Explain the Pathogenesis of Gating Class Cystic Fibrosis Mutations', in Molecular Dynamics to Explain the Pathogenesis of Gating Class Cystic Fibrosis Mutations, Elsevier, Boston MA (virtual), Vol. 120, pp. 247a, presented at Biophysical Society Meeting 2021, Boston MA (virtual), 22 February 2021 - 26 February 2021,

Preprints | 2021

Wong S; Awatade N; Astore M; Allan K; Carnell M; Slapetova I; Chen P-C; Capraro A; Fawcett L; Whan R; Griffith R; Ooi C; Kuyucak S; Jaffe A; Waters S, 2021, In silicoand functional characterisation of an ultra-rareCFTRmutation identifies novel lasso motif interactions regulating channel gating,

Preprints | 2021

Wong S; Awatade N; Astore M; Allan K; Carnell M; Slapetova I; Chen P-C; Setiadi J; Pandzic E; Fawcett L; Widger J; Whan R; Griffith R; Ooi C; Kuyucak S; Jaffe A; Waters S, 2021, Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect,

Conference Papers | 2020

Allan K; Awatade N; Wong S; Jaffe A; Waters S, 2020, 'COMBINATION THERAPY ORKAMBI® (VX‐770/VX‐809) IMPROVES FUNCTION FOR A RARE CFTR MUTATION R117H IN PATIENT‐DERIVED AIRWAY CELL MODELS', in Respirology, Wiley, Melbourne - cancelled due to COVID., presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne - cancelled due to COVID.,

Conference Abstracts | 2020

Allan K; Awatade N; Wong S; Turgutoglu N; Jaffe A; Waters S, 2020, 'COMBINATION THERAPY ORKAMBI (R) (VX-770/VX-809) IMPROVES FUNCTION FOR A RARE CFTR MUTATION R117H IN PATIENT-DERIVED AIRWAY CELL MODELS', in RESPIROLOGY, WILEY, Vol. 25, pp. 36 - 36,

Conference Abstracts | 2020

Awatade NIO; Wong S; Jaffe A; Ooi KC; Waters S, 2020, 'INTESTINAL CURRENT MEASUREMENT AS DIAGNOSTIC AND SURROGATE MARKER OF CFTR FUNCTION IN CF', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at INTESTINAL CURRENT MEASUREMENT AS DIAGNOSTIC AND SURROGATE MARKER OF CFTR FUNCTION IN CF, Melbourne, Australia_Cancelled due to COVID-19,

Conference Abstracts | 2020

Fawcett L; Wakefield C; Widger J; Jaffe A; Waters S, 2020, 'ACCEPTABILITY OF USING PERSONALISED MINI‐ORGAN‐AVATARS TO ACCELERATE DRUG DISCOVERY AND PREDICT DRUG RESPONSE IN CYSTIC FIBROSIS PATIENTS', in TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne - cancelled due to COVID, presented at TSANZSRS 2020, Melbourne - cancelled due to COVID,

Conference Abstracts | 2020

Hewson C; Wong S; Awatade N; Bridge W; Jaffe A; Waters S, 2020, 'A NOVEL COMPOUND FOR CYSTIC FIBROSIS THERAPY, TARGETING THE PROTEOSTASIS NETWORK', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19,

Conference Abstracts | 2020

Wong S; Awatade N; Fawcett L; Ooi KC; Jaffe A; Waters S, 2020, 'FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF RARE R352Q CFTR MUTATION IN PATIENT‐DERIVED DIFFERENTIATED NASAL EPITHELIAL CELLS AND INTESTINAL ORGANOIDS', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19,

Conference Abstracts | 2020

Wong S; Awatade N; Jaffe A; Waters S, 2020, 'ESTABLISHING PATIENT‐DERIVED NASAL SPHEROIDS AS A NON‐INVASIVE PERSONALISED MODEL FOR ASSESSING CFTR MODULATORS EFFECTIVENESS IN PATIENTS WITH CF', in Respirology, Wiley, Melbourne, Australia_Cancelled due to COVID-19, presented at TSANZ20_The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health, Melbourne, Australia_Cancelled due to COVID-19,

Conference Papers | 2019

Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'THE HUMAN INTESTINAL PROTEOME IN CHILDREN WITH CYSTIC FIBROSIS', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, CA, San Diego, pp. S1153 - S1153, presented at Digestive Disease Week (DDW), CA, San Diego, 18 May 2019 - 21 May 2019,

Conference Abstracts | 2019

Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2019, 'THE INTESTINAL PROTEOME IN CHILDREN WITH CYSTIC FIBROSIS DIFFERS FROM HEALTHY CONTROLS', in PEDIATRIC PULMONOLOGY, WILEY, Vol. 54, pp. S265 - S265,

Conference Abstracts | 2019

Fawcett L; Turgutoglu N; Awatade N; Wong S; Widger J; Jaffe A; Waters S, 2019, 'COMPARISON OF TWO DIFFERENT CYTOLOGY BRUSHES FOR COLLECTION OF NASAL MUCOSAL CELLS', in RESPIROLOGY, WILEY, Vol. 24, pp. 115 - 115,

Conference Abstracts | 2019

Hng Y; Waters S; Chen Y; Thomas P; Herbert C, 2019, 'EXOSOME-RELATED MEDIATORS IN SERUM AND EXHALED BREATH CONDENSATE IN SARCOIDOSIS', in RESPIROLOGY, WILEY, Vol. 24, pp. 116 - 116,

Conference Abstracts | 2019

McKay IR; Coffey MJ; Doumit M; Bramley L; Sharp M; Kasparian N; Chuang S; Stelzer-Braid S; Waters S; Thomas T; Jaffe A; Katz TE; Ooi CY, 2019, 'A GUT FEELING: CORRELATING DIETARY INTAKE WITH THE GASTROINTESTINAL AND RESPIRATORY MICROBIOTA IN CYSTIC FIBROSIS', in PEDIATRIC PULMONOLOGY, WILEY, Vol. 54, pp. S261 - S262,

Preprints | 2019

Sprague D; Waters SA; Kirk JM; Wang JR; Samollow PB; Waters PD; Calabrese JM, 2019, Non-linear sequence similarity between the Xist and Rsx long noncoding RNAs suggests shared functions of tandem repeat domains,

Conference Papers | 2019

Waters S; Awatade N; Wong S; Hewson C; Fawcett L; Ooi K; Widger J; Jaffe A, 2019, 'TRANSFORMATIVE THERAPIES FOR ULTRA-RARE CFTR MUTATIONS IN PRIMARY PRE-CLINICAL MODELS', in RESPIROLOGY, WILEY, pp. 141 - 141,

Conference Papers | 2019

Waters S; Villamizar O; Jaffe A; Morris K, 2019, 'Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator', in Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator, WILEY, pp. S183 - S184, presented at 33rd Annual North American Cystic Fibrosis Conference,

Conference Papers | 2018

Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2018, 'The human intestinal proteome in children with cystic fibrosis', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 144 - 144,

Conference Abstracts | 2018

Prentice B; Hameed S; Verge C; Ooi C; Strachan R; Waters S; Widger J, 2018, 'HYPERGLYCAEMIA IN YOUNG CHILDREN WITH CYSTIC FIBROSIS CORRELATES WITH INFECTION AND NEUTROPHIL BURDEN ON BRONCHOALVEOLAR LAVAGE', in RESPIROLOGY, WILEY, Vol. 23, pp. 34 - 34,

Media | 2019

Waters S; Jaffe A, 2019, AVATARS: A revolution in cystic fibrosis treatment. INSPIRE Research Australia,

Media | 2019

Waters S; Jaffe A, 2019, Avatars-a-game-changer-for-children-with-cystic-fibrosis,

Media | 2019

Waters S; Jaffe A, 2019, New treatment giving hope to kids with cystic fibrosis,

Media | 2019

Waters S; Jaffe A, 2019, Patients’ avatars being used to test cystic fibrosis drugs,

Media | 2018

Waters S; Prentice B; Jaffe A, 2018, Avatars take lead role in future CF therapy.,

Scheme: Ideas Grants
Funding agency: National Health & Medical Research Council��
Grant name: Towards Personalised Cystic Fibrosis Medicine: Functional characterisation and targeted therapies for rare CF Transmembrane Regulator (CFTR) mutations using patient-derived organoids
Role:��CIA, ��logo Grant number:��RG191611��Start date: 1 January 2020

Scheme: 2019 Gene Therapy Innovation Grant
Funding agency: Cystic Fibrosis Community Care��
Grant name: Nanoparticle��nanoparticle gene addition therapy in primary differentiated CF airway cell models.
Role:��Sole CI, ��logo Grant number:��RG194254��Start date: 1 January 2020

Scheme: Orphan Disease Center Million Dollar Bike Ride Grant Program
Funding agency: Penn Medicine Orphan Disease Centre |��University of Adelaide��
Grant name: Airway Cell Therapy for Cystic Fibrosis Nonsense Mutations
Role:��co-CI, ��logo Grant number:��RG192792��Start date: 1 June 2019

Scheme: DAVID MILLAR GILES INNOVATION GRANT
Funding agency: CYSTIC FIBROSIS AUSTRALIA
Grant name: an australian alliance of personalised lab grown mini-organs to save the rarest of them all
Role: Sole CI, ��logo Grant number: RG191126��Start date: 1 August 2019
��

Scheme: TSANZ VERTEX PAEDIATRIC CYSTIC FIBROSIS AWARD
Funding agency: THORACIC SOCIETY OF AUSTRALIA AND NEW ZEALAND (TSANZ)
Grant name: a novel compound for cystic fibrosis therapy, targeting proteostasis network.
Role: Sole CI, ��logo Grant number: RG192793 Start date: 17 July 2019

Scheme: NSW HEALTH PAEDIATRIC PRECISION MEDICINE SHARED GRANT
Funding agency: PAEDIATRIO LIMITED
Grant name: ppm 1: centralized capacity to develop functional genomics for paediatric precision medicine
Role: CIB, ��logo Grant number: RG192369, Start date: 1 June 2019

Scheme: REBECCA L. COOPER MEDICAL��PROJECT GRANTS
Funding agency: REBECCA L. COOPER MEDICAL RESEARCH FOUNDATION
Grant name: personalised lab grown mini-lungs to predict effect of therapies in patients with cystic fibrosis
Role: Sole CI, ��logo Grant number: RG182229, Start date: 1 January 2019

Scheme: CONTRACT RESEARCH
Funding agency: PAEDIATRIO LIMITED
Grant name: microscope funding for drug discovery and efficacy testing
Role: CIB, ��logo Grant number: RG182726, Start date: 24 October 2018

Scheme: VERTEX INNOVATION AWARDS
Funding agency: VERTEX PHARMACEUTICALS (CH)
Grant name: exo-cf; exosomal biomarkers for early prediction of cystic fibrosis related diabetes (cfrd)
Role: CIA, ��logo Grant number: RG181847, Start date: 22 March 2019

Scheme: ACFRT INNOVATION GRANT
Funding agency: CYSTIC FIBROSIS RESEARCH LIMITED QLD
Grant name: Rna therapeutics: novel paradigm in mutation independent cf therapy
Role: CIA, ��logo Grant number: RG173352, Start date: 5 March 2018

Scheme: BOOSTING BUSINESS INNOVATION PROGRAM
Funding agency: NSW DEPARTMENT OF INDUSTRY
Grant name: in vitro investigation of the potential efficacy of thiols to treat cystic fibrosis - techvoucher
Role: CIA, ��logo Grant number: RG161881-T Start date: 23 June 2018

Scheme: CONTRACT RESEARCH
Funding agency: BIOSPECIALTIES AUSTRALIA PTY LTD
Grant name: in vitro investigation of the potential efficacy of thiols to treat cystic fibrosis
Role: CIA, ��logo Grant number: RG181150, Start date: 4 June 2018

Young Tall Poppy Science Award	Australian Institute of Policy and Science \|NSW Young Tall Poppy Science Award	2022
Best EMCR Poster Award	Australian Academy of Science \| AU-China Precision Medicine Symposium	2019
EMCR Travel Award	Australian Academy of Science \| AU-China Precision Medicine Symposium	2019
Travel Award	Australian Academy of Science \| Science at the Shine Dome Early-and Mid-Career Researchers Program	2018
Finalist	Annual Quality and Innovation Awards \| The Sydney Children’s Hospital Network	2018
Travel Award	SIDRA Functional Genomics Towards Precision Medicine Symposium. Doha Qatar	2017
Travel Award	Vice-Chancellor's HDR \| Australian National University (ANU)	2012
Best PhD Candidate Talk Award	Genetics Society of Australasia Conference 2010	2010
Travel Award	University of Otago, New Zealand	2008
Best Poster Presentation Award	Molecular Basis of Cancer and Development Meeting 2007	2007

My current research has a strong translational focus in three key areas of

(i)��stem cell biology involving disease modeling and��regenerative medicine

(ii)��prognostic and diagnostic exosomal biomarker discovery for CF related diabetes,

(iii) CFTR restoring therapeutics in patient derived organoids using a variety of delivery approaches including viral and nanoformulations.

(iv) host-pathogen interactions for viral and bacterial infections.

The Thoracic Society of Australia and New Zealand Research Committee member (since 2020)

��logo Early Career Academic Network Executive Committee member (since 2020)

��logo- Faculty of Medicine Co-chair Early Career Academic Network (since 2020)

Memberships:

��logo Australian Centre for NanoMedicine

Australian Living Organoid Alliance (ALOA)

The Thoracic Society of Australia and New Zealand (TSANZ)

��logo Australian Centre for NanoMedicine

Women in Research Network member, ��logo

Australian Society for Medical Research

Genetic Society of AustralAsia (GSA)

Community Engagement

Cystic Fibrosis Foundation Australia

My Research Supervision

PhD student (July 2016- current)

Hons and Masters students

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