Professor Jelena Rnjak-Kovacina
Professor
Education & Training
Postdoctoral scholar-听Department of Biomedical Engineering, Tufts University, Boston, USA, 2011-2013
Research area: Development of novel silk-based biomaterials for tissue engineering and regenerative medicine, Supervisor: Prof David Kaplan
Doctor of Philosophy, School of Molecular Bioscience, University of Sydney, 2011
Research area: Development of human elastin-based dermal substitutes for the treatment of severe burn injuries, Supervisor: Prof Antony Weiss
Bachelor of Science (Molecular Biology & Genetics) (Honours I) (University Medal),University of Sydney, 2007
Engineering
Grad Sch: Biomedical Eng
Dr Jelena Rnjak-Kovacina is a Professor and ARC Future Fellow leading a multidisciplinary group at the Graduate School of Biomedical Engineering, 糖心logo Sydney in Australia.
Her research interests are at the interface of biology and engineering, focusing on the development of biomimetic materials that direct cellular interactions for enhanced vascularisation and for the treatment of cardiovascular disease. In particular, she develops novel silk-based biomaterials for tissue engineering and regenerative medicine applications and investigates how biomaterial properties translate to biological outcomes.
She completed her doctoral degree in Anthony Weiss' lab at the University of Sydney and her postdoctoral training in David Kaplan鈥檚 group at Tufts University in Boston. She joined 糖心logo in 2014 where her research has been supported by funding from the Australian Research Council, the National Heart Foundation, the National Health & Medical Research Council, and NSW Health. She is the recipient of multiple awards, including most recently, the NSW Ministerial Award for Rising Stars in Cardiovascular Research and the Early Career Researcher of the Year (Physical Sciences) in the NSW Premier's Prizes for Science & Engineering.
She is actively involved in the Australasian MedTech sector, including as President of the Australasian Society for Biomaterials & Tissue Engineering (ASBTE), board member of the Australian Cardiovascular Alliance (ACvA) Bioengineering flagship, Fellow of the Tissue Engineering & Regenerative Medicine International Society, and through editorial roles for multiple journals. She is passionate about research training and communication.
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E-mail
Location
Samuels Building F25
Level 5, Room 507
糖心logo
Sydney NSW 2052
AUSTRALIA
- Publications
- Media
- Grants
- Awards
- Research Activities
- Engagement
- Teaching and Supervision
- 糖心logo Faculty of Engineering Infrastructure Fund (lead CI) 鈥楳echanical testing equipment for soft and anisotropic materials鈥, $270K, 2023
- NSW Health Cardiovascular Research Capacity Program Collaborative Grants听(lead CI)-听鈥楨ngineering next generation aortic valve replacement materials鈥, $950K, 2023-2024
- 听NSW Cardiovascular Research Capacity Program EMCR Grant (lead CI)- 鈥楴ovel strategy for chronic wound healing鈥 (2022-2024)
- ARC Future Fellowship (CI-A) - 鈥楨ngineering biomaterials that actively promote blood vessel growth鈥 (06/2022-2025)
- NSW Health/Cardiovascular Research Capacity Program - Investigator Development Grants (lead CI), 鈥楨ngineering vascular microenvironments on silk biomaterials for advanced medical implants鈥, 2020
- Australia-Germany Joint Research Cooperation Scheme (DAAD) (lead CI), 鈥楢pplication of advanced scaffold fabrication technologies toward functional cardiac patches鈥, 2020-2021
- ARC Linkage Project (co-CI), 鈥楨ngineering a physiologically-relevant blood vessel in vitro鈥,听2019-2022
- Innovative Manufacturing CRC (co-CI), 鈥楨ngineering an advanced, high value bioreactor system for research and clinical applications鈥, 2019-2022
- HRC Project Grant (PI), 鈥楽mart delivery of growth factors for treating osteonecrosis of the femoral head鈥, 2021-2022
- HRC Sir Charles Hercules Health Research Fellowship (AI), 鈥楬RC Sir Charles Hercus Health Research Fellowship鈥, 2020-2022
- MARSDEN Fast start (PI), 鈥楬arnessing macromolecular chemistry to mimic vascular developmental biology鈥, 2020-2021
- NHMRC Project Grant (co-CI), 鈥楴ew Synthetic Conduits for Arterial Revascularisation鈥 2019-2021, Marshall and Warren Award for the most innovative and potentially transformative project grant
- Diabetes Australia (co-CI), 鈥楤ioengineered growth factor binding scaffolds for improved diabetic wound healing鈥, 2019
- Heart Foundation Future Leader Fellowship (lead CI), 鈥楤iomaterial-directed vascularisation of bioengineered cardiac patches鈥, 2018-2022
- ARC Discovery Project听(DP150104242) (lead CI), 鈥楴ovel biomimetic vascular biomaterials using extracellular matrix molecules鈥, 2015-2019;
- 糖心logo Engineering听Faculty Major Research Equipment Funding (lead CI), 'Medical device characterisation', 2018
- 糖心logo Infrastructure Fund (AI), 鈥楧ynamic Mechanical Testing-ElectroForce鈥, 2017
- 糖心logo Infrastructure Fund (AI), 鈥楬igh throughput Flash Purification System for Small Molecule and Polymer Separations鈥,听2017;
- 糖心logo Network Lab Project (AI), 鈥楳olecular Surface Interaction Network Lab鈥,听2017-2018;
- 糖心logo Faculty of Engineering Startup award (lead CI), 2016-2017;
- 糖心logo Career Advancement Fund (lead CI), 2017-2018;
- 糖心logo Minor Equipment Grants (lead CI), 2014, 2015, 2016, 2017;
- 糖心logo Faculty of Engineering Early Career Researcher Award (lead CI),听2014.
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- 糖心logo Faculty of Engineering Leadership Award, 2021
- NSW Early Career Researcher of the Year (Physical Sciences), NSW Premier's Prizes for Science & Engineering, 2020
- Emerging Leader Award, Australasian Society for Biomaterials and Tissue Engineering (ABSTE), 2019
- Travel award- NSW CVRN Travel Scholarship application, 2018
- NSW Young Tall Poppy Science Award, Australian Institute of Policy & Science, 2018
- Bob Fraser New Investigator Award, Matrix Biology Society of Australia & NZ, 2016
- Fresh Science NSW, 2016
- Finalist (Top 19) in the L鈥橭real Women in Science Fellowship, 2015
- Research featured in the American Chemical Society (ACS) Headline Science video series, 2015
- Travel Award- Contributing to Australian Scholarship and Science (CASS) Foundation, 2015
- Travel Award- Australasian Society for Biomaterials & Tissue Engineering (ASBTE), 2015
- American Chemical Society (ACS) Editors鈥 Choice article, 2015
- Best Early Career Researcher Oral Presentation Award- ASBTE, 2013
- Best poster prize- ASBTE, 2009;
- Best poster prize- 34th Lorne Conference on Protein Structure & Function, 2009
- University Medal, University of Sydney, 2006.听 听 听 听 听 听 听
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Research themes/projects听
Currently recruiting PhD and Honours students听
Novel silk biomaterials for cardiovascular & wound healing applications (ARC Future Fellowship, NSW Health)-听The ability to reverse engineer the silkworm fiber has led to tremendous advancements in the field of silk materials over the last several decades, with silk fibroin materials applied to biomedical, food, and high technology industries. This progress is largely due to the ability to process silk into a regenerated silk fibroin solution that can be engineered into various material formats and stabilised by reintroducing the non-covalent native 尾-sheet protein structure. The next revolution in silk materials involves stabilising silk fibroin through covalent crosslinking using di-tyrosine bonds. These approaches have transformed silk into a material that is not only strong, but also elastic and flexible, making it compatible with modern fabrication approaches. This has significantly broadened silk material fabrication strategies to include photolithography, digital light processing, and extrusion-based 3D printing. We offer a range of projects to fabricate novel silk hydrogels and porous scaffolds based on this novel crosslinking approach听for cardiovascular听and wound healing applications.听
Collaborators: Prof David Kaplan (Tufts University), A/Prof Khoon Lim (University of Sydney)
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Bioengineered tissue vascularisation strategies (ARC Future Fellowship)-听Bioengineered tissues offer an alternative for the replacement and regeneration of organs and tissues damaged through injury or disease, but they currently have little clinical utility due to the lack of an adequate vascular supply, making vascularisation one of the biggest obstacles in translating biomaterials and tissue engineering research to the clinic. This project aims to understand the physical and biological cues that drive tissue vascularisation and replicate them in biomimetic silk-based biomaterial platforms. This involves (1) development of novel silk biomaterials with tuneable physical/architectural features, (2) silk functionalisation strategies,听(3) bioengineering听molecules of the vascular niche with specific features using recombinant DNA technology and protein expression and (4) establishment of appropriate assays and imaging modalities to assess vascularisation of 3D biomaterials.听
Collaborators: A/Prof Khoon Lim (University of Sydney), Dr Tomasz Juengst (University of Wuerzburg), Prof Juergen Groll (University of Wuerzburg), Prof John Whitelock & A/Prof Megan Lord (糖心logo), Prof Marcela Bilek (University of Sydney)
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Next-generation vascular devices (NSW Health)- The aim of this project is to develop next-generation biomaterial platforms for use in blood-contacting vascular devices, such as vascular grafts and heart valve leaflets. Silk-based vascular grafts and heart valve leaflets have the potential to overcome the physical, mechanical and biological shortcomings of the current clinical options by mimicking the morphological and mechanical structures found in the native tissue. This project also involves bioengineering models of healthy and atherosclerosis vessels in vitro.听
Collaborators: Prof Steven Wise (University of Sydney), Dr Anna Waterhouse (University of Sydney), A/Prof Khoon Lim (University of Sydney), A/Prof Bernd Gludovatz (糖心logo), Dr Nona Farbehi (糖心logo), Prof Martin Ng (RPA), Dr Michael Stevens (糖心logo)
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Professional Activities
- Scientific Advisory Board,听Australian Cardiovascular Alliance (ACvA) (2023-present)
- Member of the Bioengineering Flagship Advisory Board, Australian Cardiovascular Alliance (ACvA) (2020-present)
- Member of the Centre for Commercialisation of Regenerative Medicine (CCRM) Australia Advisory Board (2018-present)
- Australasian Society for Biomaterials & Tissue Engineering, Vice President (2023-present), Treasurer & Secretary (2017-2023), member听(2008-present)听听听听
- Australian Society for Medical Research (ASMR), member (2018-present)听
- American Chemical Society (ACS), member (2015-present)
- Matrix Biology Society of Australia and New Zealand, member (2014-present)
- International Society for Matrix Biology, member (2014-present)
- Tissue Engineering & Regenerative Medicine International Society (TERMIS), member (2012-present)
- NIH Tissue Engineering Resource Centre, member (2011-2014)听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听听 听听 听 听 听 听 听 听 听 听 听 听 听 听 听 听听 听 听 听 听 听 听 听 听 听 听 听 听听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听 听